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Clinical Guides

Evidence-based references on skin conditions, treatments, diagnostic technology, and prevention — reviewed by board-certified dermatologists.

Treatment

5-Fluorouracil (5-FU) Cream

5-fluorouracil is a prescription cream that clears sun-damaged and precancerous skin across a whole area. How it works, what the reaction looks like, and how well it works.

Used for 3 conditions15 studies

Tyler Long, DO · Reviewed Jun 2026

Condition

Actinic Keratosis

Actinic keratoses are rough, scaly patches from years of sun exposure. They are the most common precancer and a direct precursor to squamous cell carcinoma, so treating them is one of the most effective ways to prevent skin cancer.

9 treatments18 studiesFirst-line: 5-fluorouracil cream

Tyler Long, DO · Reviewed Jun 2026

Condition

Atypical Moles (Dysplastic Nevi)

An atypical mole (also called a dysplastic nevus) is a harmless mole that looks a little unusual. It is not cancer. Having several of them is mostly a sign to keep an eye on your skin, not a reason to remove them all.

6 treatments11 studiesFirst-line: Regular skin checks + self-exams

Tyler Long, DO · Reviewed Jun 2026

Condition

Basal Cell Carcinoma

Basal cell carcinoma is the most common skin cancer. It grows slowly, rarely spreads, and is highly curable, especially when caught early. What it looks like, how it's diagnosed, and how it's treated.

7 treatments12 studiesFirst-line: Surgical excision

Tyler Long, DO · Reviewed Jun 2026

Patient Guide

Melanoma

Melanoma is a family of skin cancers, from melanoma in situ (almost always curable) to invasive and advanced disease. This overview explains the types and stages so you can see where a diagnosis fits, then how treatment changes by stage.

Tyler Long, DO · Reviewed Jun 2026

Condition

Melanoma In Situ

Melanoma in situ is the earliest, Stage 0 form of melanoma, confined to the top layer of skin. Because it hasn't grown deeper, removing it completely is essentially curative.

2 treatments10 studiesFirst-line: Wide local excision

Tyler Long, DO · Reviewed Jun 2026

Treatment

Photodynamic Therapy (PDT)

Photodynamic therapy uses a light-activated medicine to clear actinic keratoses and sun damage across a whole area at once. How it works, what to expect, and how well it works.

Used for 3 conditions8 studies

Tyler Long, DO · Reviewed Jun 2026

Prevention

Skin Self-Exam (ABCDE)

Checking your own skin helps you spot a new or changing mole early. Here is how to do it with the ABCDE rule and the ugly duckling sign, what a self-exam can miss, and honest answers about phone apps.

Benefit12 studies

Tyler Long, DO · Reviewed Jun 2026

Condition

Squamous Cell Carcinoma

Squamous cell carcinoma is the second most common skin cancer. Most are cured with surgery, but a higher-risk minority can spread, so risk and early treatment matter. What it looks like, how it's diagnosed, and how it's treated.

5 treatments9 studiesFirst-line: Surgical excision

Tyler Long, DO · Reviewed Jun 2026

Prevention

Sunscreen & SPF

Daily sunscreen is one of the simplest ways to lower your risk of skin cancer and slow skin aging. Here is what the research actually shows it prevents, how to use it, and honest answers to the worries about safety and vitamin D.

Benefit11 studies

Tyler Long, DO · Reviewed Jun 2026

Patient Guide

Total Body Photography

Total body photography makes a 3D map of your skin so a dermatologist can spot new and changing moles over time. Here is how the technology grew from flat photos to a 3D map, where the evidence is strongest, and what it does not do.

Tyler Long, DO · Reviewed Jul 2026

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Skin Cancer Condition Guides: Melanoma, BCC, SCC & More | SpotDoc